Tools for the Microbiome: Nano and Beyond.

نویسندگان

  • Julie S Biteen
  • Paul C Blainey
  • Zoe G Cardon
  • Miyoung Chun
  • George M Church
  • Pieter C Dorrestein
  • Scott E Fraser
  • Jack A Gilbert
  • Janet K Jansson
  • Rob Knight
  • Jeff F Miller
  • Aydogan Ozcan
  • Kimberly A Prather
  • Stephen R Quake
  • Edward G Ruby
  • Pamela A Silver
  • Sharif Taha
  • Ger van den Engh
  • Paul S Weiss
  • Gerard C L Wong
  • Aaron T Wright
  • Thomas D Young
چکیده

The microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. These technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Next Generation Sequencing and its Application in the Study of Microbiome in Plant Diseases Suppressive Soils

Progress in next-generation sequencing has played a significant role in ecological studies of microbial populations. These advances have led to a rapid evaluation in metagenomics studies (analysis of DNA of microbial communities without the need to culture). Many statistical and computational tools and metagenomics databases have led to the discovery of huge amounts of data. In this research, i...

متن کامل

Human Microbiome

Humans are almost identical in their genetic pattern, but the slight differences in our DNA lead to remarkable phenotypic variation among the human population. There are a variety of microbial communities and their genes (microbiomes) in the human body that play an essential role in human health and disease. The microbes inhabiting our bodies is quite a bit more variable, with only a third of i...

متن کامل

A Metagenomic Analysis of Lung Microbiome in Chemically Injured and Healthy Individuals

Background and Aim: The role of the lung microbiome in respiratory complications associated with chemicals such as sulfur mustard or chlorine gas has yet to be determined. The aim of this study was to compare the structure and composition of the lung microbiome in chemically injured and healthy individuals in order to understand the relation between the population of the lung microbiota and res...

متن کامل

A Review of The Role of The Microbiome on Immune Responses and Its Association With Cystic Fibrosis

In recent years, the microbiome has been recognized as a key regulator of immune responses. Evidence suggests that changes in the microbiome can lead to chronic disease and even exacerbation of the disease. Impairment of innate immunity resulting from microbial incompatibility may worsen host susceptibility to infection and exacerbate chronic lung diseases. Specific microbes play a key role in ...

متن کامل

Evaluation of vitamins diversity produced by probiotics in the microbiome and introduction of selected species

Vitamins are important micronutrients and are often precursors of enzymes that living cells need to perform biochemical reactions. Because humans cannot biosynthesize most vitamins, therefore, they must be obtained exogenously. Although a variety of vitamins are found in most foods, many people's vitamin deficiencies still occur mainly due to malnutrition as a result of inadequate food consumpt...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • ACS nano

دوره 10 1  شماره 

صفحات  -

تاریخ انتشار 2016